Transforming personalised medicine with leading microbiome science

Microbiotica identifies gut bacteria linked to phenotype with unprecedented precision in order to discover and develop live bacterial therapeutics and biomarkers

Company

Microbiotica was launched in December 2016 with the aim of creating a global leader to exploit the leading microbiome science built at the Wellcome Trust Sanger Institute. The company retains a close association with the Sanger Institute and its founders and is based at the Wellcome Genome Campus, Cambridge UK.

The Microbiome

The human body is host to trillions of microbes, comprising several hundred species per person residing mainly in the gastrointestinal tract. They are generally in a symbiotic relationship, impart protective functions to the gut, and regulate immunological, metabolic and neuronal functions throughout the body. Disruptions to the microbiome are implicated in a host of disorders, for example IBD, IBS, metabolic disease, cancer and Parkinson’s, and it is now clear that gut microbiota regulate the response to cancer immunotherapies. Thus the microbiome represents a major new opportunity in the discovery of medicines and biomarkers. The biggest barrier to this has been the inability to precisely identify a patient’s bacteria and then to undertake functional studies in order to understand the biology.

Platform

The Microbiotica platform is based on world leading tools developed at the Wellcome Trust Sanger Institute that unblock the barriers to discovery. These are founded on a unique capability to culture, characterise and phenotype the majority of a patient’s gut bacteria, enabling precise association of bacteria to function for the first time. They also include the leading microbiota culture collection and reference genome database which provide resources for precise metagenomic analysis and functional studies, and humanised in vitro and in vivo models of disease. Using these tools Microbiotica starts programs with deep analysis of samples from clinical trials and progresses medicines and biomarkers through lab testing back into the clinic.

Pipeline

Microbiotica has programs in IBD, immune-oncology and Clostridium difficile, developing medicines and biomarkers based on microbiota. These programs start with deep metagenomic and culture-based analysis of patient samples linked to phenotype before testing of candidate bacteria in advanced human in vitro and in vivo models. The company’s C. difficile defined live bacterial therapeutic asset will be used to validate our manufacturing and delivery technologies.

 

Latest News
Microbiotica Wins Life Sciences Company of the Year at Cambridge Independent Awards

Cambridge, UK, 2 November 2018 – Microbiotica, a leading player in microbiome-based therapeutics and biomarkers, announces that it has been named Life...

Microbiotica Participates in Microbiome Panel Discussion at this year’s Bio-Europe®

Cambridge, UK, 30 October 2018 – Microbiotica, a leading player in microbiome-based therapeutics, today announced that it will join the microbiome...

Microbiotica Attracts Equity Investment from Seventure’s Health for Life Capital™ Fund

·     Seventure Partners, a specialist investor in the microbiome, commits new funding from Health for Life Capital™ and strengthens...

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